Sumedh Rajendran completed a BFA from the College of Fine Arts, Trivandrum, Kerala, 1994 and an MFA from the Delhi College of Art, 1999.

His solo exhibitions include Water without Memory, Sakshi Gallery, Mumbai, 2017; Split Distance, Vadehra Art Gallery, 2015; Dual Liquid, Vadehra Art Gallery, New Delhi, 2010; Chemical Smuggle, Grosvenor Vadehra, London, 2008; Final Call, Anant Art Centre, New Delhi, 2007; Street Fuel Blackout, Sakshi Gallery Mumbai, 2006; and Pseudo-Homelands, Rohtas Art Gallery, Lahore. Rajendran has widely exhibited his works in various international exhibitions. These include participation in Indian Highway at Astrup Fearnley Museum, Norway; On the Road to Next Milestone, part of Indian highway at HEART, Herning, Denmark; Zones of Contact, Propositions on the Museum, Kiran Nadar Museum of Art, New Delhi; and Kochi-Muziris Biennale, Kochi, among others.

The artist lives and works in New Delhi, India.